PLEASE FOLLOW THE INSTRUCTIONS BELOW:ZERO (0) PLAGIARISM5 REFERENCES NO MORE THAN 5 YEARS, OR LESSPLEASE SEE ATTACHED RUBRIC DETAILS AND FOLLOW APA FORMAT.NO RUNNING HEAD, AND PLEASE ADHERE TO THE ONE (1) PAGE AS INSTRUCTEDThe unapproved use of approved drugs, also called off-label use, with children is quite common. This is because pediatric dosage guidelines are typically unavailable, since very few drugs have been specifically researched and tested with children.When treating children, prescribers often adjust dosages approved for adults to accommodate a child’s weight. However, children are not just “smaller” adults. Adults and children process and respond to drugs differently in their absorption, distribution, metabolism, and excretion.Children even respond differently during stages from infancy to adolescence. This poses potential safety concerns when prescribing drugs to pediatric patients. As an advanced practice nurse, you have to be aware of safety implications of the off-label use of drugs with this patient group.To PrepareReview the interactive media piece in this week’s Resources and reflect on the types of drugs used to treat pediatric patients with mood disorders.Reflect on situations in which children should be prescribed drugs for off-label use.Think about strategies to make the off-label use and dosage of drugs safer for children from infancy to adolescence. Consider specific off-label drugs that you think require extra care and attention when used in pediatrics.Write a 1-page narrative in APA format that addresses the following:Explain the circumstances under which children should be prescribed drugs for off-label use. Be specific and provide examples.Describe strategies to make the off-label use and dosage of drugs safer for children from infancy to adolescence. Include descriptions and names of off-label drugs that require extra care and attention when used in pediatrics.Therapy for Pediatric Clients with Mood DisordersAn African American Child Suffering From DepressionBACKGROUND INFORMATIONThe client is an 8-year-old African American male who arrives at the ER with his mother. He is exhibiting signs of depression.Client complained of feeling “sad”Mother reports that teacher said child is withdrawn from peers in classMother notes decreased appetite and occasional periods of irritationClient reached all developmental landmarks at appropriate agesPhysical exam unremarkableLaboratory studies WNLChild referred to psychiatry for evaluationMENTAL STATUS EXAMAlert & oriented X 3, speech clear, coherent, goal directed, spontaneous. Self-reported mood is “sad”. Affect somewhat blunted, but child smiled appropriately at various points throughout the clinical interview. He denies visual or auditory hallucinations. No delusional or paranoid thought processes noted. Judgment and insight appear to be age-appropriate. He is not endorsing active suicidal ideation, but does admit that he often thinks about himself being dead and what it would be like to be dead.You administer the Children’s Depression Rating Scale, obtaining a score of 30 (indicating significant depression)RESOURCES§ Poznanski, E., & Mokros, H. (1996). Child Depression Rating Scale–Revised. Los Angeles, CA: Western Psychological Services.ALL THREE MEDICATIONS ARE PROVIDED BELOW AND DECISION POINTS TO FOLLOW.Decision Point OneBegin Zoloft 25 mg orally dailyRESULTS OF DECISION POINT ONEClient returns to clinic in four weeksNo change in depressive symptoms at allDecision Point TwoIncrease dose to 37.5 mg orally dailyRESULTS OF DECISION POINT TWOClient returns to clinic in four weeksDepressive symptoms decrease by 20%. Client reports feeling a little bit betterDecision Point ThreeIncrease to 50 mg orally dailyGuidance to StudentAt this point, sufficient symptom reduction has not been realized. Should either increase dose or consider different SSRI. At 8 weeks post-initiation of therapy, there should have been a significant (as defined as 50%) decrease in symptoms. This would be considered an adequate trial of antidepressant and change in dose or to a different agent would be appropriate.Decision Point OneBegin Paxil 10 mg orally dailyRESULTS OF DECISION POINT ONEClient returns to clinic in four weeksReduction in The Children’s Depression Rating Scale by 5 points overall, but with complaints of nausea, vomiting, and diarrheaDecision Point TwoChange to Prozac 10 mg orally dailyRESULTS OF DECISION POINT TWOClient returns to clinic in four weeksThere is a 25% reduction in symptoms, client’s side effects of nausea, vomiting, and diarrhea have resolved. Client reports that he is feeling a “little bit better”Decision Point ThreeContinue current doseGuidance to StudentYou have two equally compelling choices at this point. The client has only been taking the current drug at its current dose for 4 weeks. It would be appropriate to continue at current dose. Additionally, you could also increase the dose to 20 mg orally daily. A discussion of risk/benefits should be had with the childs guardian regarding this and collaborative decision making should occur. There is no indication at this point that augmentation agents are required as the child is showing a partial response to therapy.Decision Point OneBegin Wellbutrin 75 mg orally BIDRESULTS OF DECISION POINT ONEClient returns to clinic in four weeksChild is unable to fall asleep at nightDecision Point TwoChange to Lexapro 10 mg orally dailyRESULTS OF DECISION POINT TWOClient returns to clinic in four weeksChild is tolerating Lexapro, and is sleeping at night. There is a 40% reduction in symptomsDecision Point ThreeContinue current doseGuidance to StudentAt this point, there is no indicating that you should change back to Wellbutrin as the child is tolerating the current medication without mention of side effects. Also, the child is experiencing a reduction in symptoms. You could also increase the dose to 15 mg orally daily, but the child has only been taking the drug for 4 weeks at this point. It may be more prudent to give the current therapy an additional 4 weeks before making any decisions to change current dose.
https://affordablenursingwriters.com/wp-content/uploads/2020/08/Affordable-nursing-300x66.png 0 0 Joseph https://affordablenursingwriters.com/wp-content/uploads/2020/08/Affordable-nursing-300x66.png Joseph2022-02-04 20:22:222022-02-04 20:22:22Assignment: Off-Label Drug Use in Pediatrics
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